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81 Due to the increased permeability of the BBB in hyperglycemia and obesity, SGLT-2is and GLP-1RAs are likely to pass through the compromised BBB

Why GLP-1 Medications Are Gaining Attention GLP-1s (glucagon-like peptide-1 receptor agonists) help regulate appetite and blood sugar by: Reducing hunger Enhancing satiety Improving insulin secretion and slowing gastric emptying Reducing food cravings and food noise My role as a dietitian in GLP-1 use As a registered dietitian and nutritionist, I work with many clients taking Ozempic, Wegovy, Saxenda, and Mounjaro [For a list of the GLP-1 medications, see Figure 1 of this article]

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Reduced MC4R signaling alters nociceptive thresholds associated with red hair