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However, the significant weight loss and improved metabolic health it produces can lead to meaningful increases in endogenous testosterone production, particularly in men with obesity-related hypogonadism

This success prompts future studies to not only confirm the findings in larger cohorts but also to explore similar avenues

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In states of insulin resistance, impairments in phosphatidylinositol 3-kinase (PI3K) and mitogen-activated protein kinase (MAPK) signaling pathways can disturb the balance between nitric oxide (NO) production and endothelin-1 secretion, resulting in endothelial dysfunction [56,57,58] (refer to Fig