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*Correspondence: Ren-You Gan, [email protected] Wu, [email protected] These authors have contributed equally to this work and share first authorship This article was submitted to Food Chemistry, a section of the journal Frontiers in Nutrition Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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The transcription factor nuclear erythroid 2-related factor (NRF2) is a major component of the cells response to oxidative stress 34,35,36 and is expressed at very high levels in epidermal cells 37