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Animal research using mice was conducted under a protocol approved by the UC Irvine Institutional Animal Care and Use Committee (IACUC) in compliance with the Animal Welfare Act and other federal statutes relating to animals and experiments using animals (Burke lab animal use protocol AUP-22-005 and AUP-25-004)

These are: Rhodiola: a botanical that has been found to improve task performance and lower serum cortisol levels in 576mg doses63 Ginseng: a root that, according to a 2024 review, contains components that could be novel candidates for cognitive improvement in older individuals for their ability to improve [subjective memory impairment] cognition when taken in doses of 100600mg per day64 (Ashwagandha used to be part of the mix but has since been cut

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