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Conditions include alcoholic liver disease, viral hepatitis, cirrhosis, and primary or metastatic liver cancer Renal dysfunction : Impaired kidney function reduces B12 elimination, causing accumulation even with normal intake Haematological conditions : Myeloproliferative neoplasms, chronic myeloid leukaemia, polycythaemia vera, and hypereosinophilic syndrome increase transcobalamin production, elevating total serum B12 Laboratory interference : Macro-B12 (immunoglobulin-bound B12) and assay interference can cause spuriously elevated results without true excess In clinical practice, unexplained hypercobalaminaemia should prompt investigation for underlying disease, particularly in patients without obvious supplementation history
FUNDC1 regulates mitochondrial dynamics at the ER-mitochondrial contact site under hypoxic conditions
Additionally, miRNA-144 has been identified as having increased expression in both the early phase and end-stage of OA, highlighting its potential as a therapeutic target [53]
The key is synergy, not rivalry
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