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In the absence of amino acids such as cystine, cells promote translation of ATF4 via the general control non-repressor 2 (GCN2) -eukaryotic initiation factor (eIF2a) signaling pathway, which promotes transcription of genes involved in amino acid metabolism and stress response, including SLC7A11, enabling cells to cope with amino acid starvation

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Autophagy regulates steroid production by mediating cholesterol trafficking in endocrine cells

However, in some cases, fibroids can cause heavy periods, pain in the lower belly, or pressure on the bladder