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GHRH analogs These act through the GHRH receptor: CJC-1295 with DAC CJC-1295 No DAC / Modified GRF (1-29) Sermorelin Tesamorelin Native GHRH / GRF fragments GHRPs and ghrelin mimetics These act through the growth hormone secretagogue receptor pathway: Ipamorelin GHRP-2 GHRP-6 Hexarelin Alexamorelin / GHRP-1 MK-677 / Ibutamoren, though this is non-peptide This section is useful for SEO because it expands the article beyond a narrow three-way comparison and establishes topical authority around the broader GH secretagogue category

Best for: Puffiness and mild vascular (bluish) dark circles Limitations: Does not treat genetic or deep pigmentation Cold Spoons or Ice Rollers Cold therapy works by constricting blood vessels, which reduces swelling and fluid buildup around the eyes

Safe for most skin types and tones

In clinical studies