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The peptide acts as an agonist at the ghrelin/GHS receptor, stimulates Gq and Go signaling, increases intracellular calcium in somatotrophs, triggers exocytosis of GH-containing vesicles, and may also stimulate GHRH release and reduce somatostatin at the hypothalamic level

This stimulation occurs via its interaction with ghrelin receptors and subsequent activation of the pituitary gland, encouraging enhanced growth hormone production

Researchers should maintain protocols documenting intended use and ensure publications reference IGF-1 LR3 as a research reagent

The gastrointestinal side effect burden could be substantial, given that CagriSema already produces higher nausea rates than either component alone