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Our results show that glutathione efflux from hepatocytes results in high local concentrations of both glutathione and cysteine in liver sinusoids, which transforms the nanoparticle surface chemistry, reduces its affinity to serum protein and significantly alters its blood retention, targeting and clearance

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These include: The severity of B12 deficiency The presence of underlying health conditions Genetic variations affecting B12 metabolism The duration of supplementation Knowing these factors helps tailor the dose to meet individual needs, ensuring the best results