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10.1038/s41467-025-60844-9 8 BoutouyrieP.ChowienczykP.HumphreyJ

In their post hoc analysis of data from subjects in the SURPASS program, the investigators compared changes in mean HbA1c (blood sugar), body weight, and cardiometabolic markers including waist circumference , lipids, and blood pressure in subjects with early-onset type 2 diabetes (N=873, 20.5%) vs later-onset type 2 diabetes (N=3394, 79.5%)

This pathway is particularly important for satellite cell activation - muscle-specific stem cells that when activated by IGF-1, re-enter the cell cycle, proliferate, and can differentiate into myoblasts that fuse with existing muscle fibers or create new muscle fibers

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