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Although the aggravating mechanism is still controversial, enhanced oxidative stress resulting from reduced oxygen delivery (hypoxia) due to anemia, IRI due to sparse erythrocytes in renal capillaries, and/or retardation of iron utilization for hemoglobin synthesis are considered the major causes (Figure 1)

Metabolic health solutions: Biosensors, data platforms, and food-as-medicine programs integrating nutrition into healthcare and daily decision-making

We identified a subset of metabolites that distinctly characterize epilepsy-associated metabolic changes, including citric acid, glutamic acid, proline, 3-methyl-2-oxovaleric acid and glucose (Fig