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Conceptually, this method is rooted in the quantitative explanation of Brownian (i.e., the random movement of particles in a fluid) independently provided in 1905, by Albert Einstein (18791955) (Einstein, 1905) and in 1906, by Marian von Smoluchowski (18721917) (Von Smoluchowski, 1906), who presented what is known now as the Smoluchowski equation, which is a cornerstone of stochastic process theory, that details the time-dependent behavior of the probability density function for a particle experiencing Brownian motion under the influence of both external forces and diffusion

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PMID: 17468262