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In line with the preclinical evidence, a number of clinical observations in NS and rotating shift workers across various populations and settings consistently suggest that NSW is associated with elevated oxidative stress and DNA damage, along with alterations in antioxidant defense systems 64

Other causes of liver injury were excluded, including HBV, HCV, and HIV infections, drug-induced hepatitis, autoimmune liver disease, fatty liver disease, malignant tumors, and pregnant women

Each component targets a distinct biological mechanism: tissue repair, wound healing, cellular regeneration, and inflammation modulation

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