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In particular, ligand-bound GPCRs are specifically phosphorylated by GRKs, and this process leads to the recruitment to phosphorylated receptors of -arrestin and the inhibition of further G protein activation by causing uncoupling from G proteins, a procedure known as GPCR desensitization

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Plaintiffs allege that manufacturers Novo Nordisk and Eli Lilly failed to adequately warn patients and healthcare providers about the risks associated with Ozempic and other GLP-1 drugs