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doi: 10.1073/pnas.2014879117

Weeks 24 through 40 continue at a slower but steady pace (approaching 24% cumulative)

The most significant recent finding: a May 2026 Lancet randomized controlled trial (108 patients, 26 weeks) found semaglutide 2.4 mg reduced heavy drinking days by 41.1 percentage points versus 26.4 on placebo, a statistically significant 13.7-point difference

3 Consumers inspired to manage their health through diet and exercise alone are adopting GLP-1-inspired eating patterns focused on portion control, fiber and protein intake and metabolic health without pharmaceutical intervention