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Tyrrell, J., Campbell, S

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Cell 185 (5), 881895e20

In innate immunity, Clostridium modulates macrophage polarization (shifting from pro-inflammatory M1 to anti-inflammatory M2), induces tolerogenic dendritic cell phenotypes to suppress excessive antigen presentation, regulates inflammatory body activity and neutrophil hyperactivation, and modulates ILC subsets to reinforce mucosal defense