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Exploring the molecular mechanisms underlying DSIPs effects, which could pave the way for the development of optimized analogs or targeted therapies

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The C18 fatty-diacid chain at Lys (with a Glu-Glu spacer) and the Aib substitution that blocks DPP-4 cleavage together produce a 7-day half-life, the longest of the three primary GLP-1 class research peptides