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Pharm Res 30(5):14471457 Madsbad S (2016) Review of head-to-head comparisons of glucagon-like peptide-1 receptor agonists

Eur J Med Chem

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That number is not just large in absolute terms, it is the largest weight-loss signal ever reported in a randomized Phase 3 trial of a GLP-1-class compound, and it arrived with additional secondary findings that reframe what "GLP-1 therapy" could eventually mean: a 75.8% reduction in osteoarthritis pain, a roughly 20% drop in LDL cholesterol, and a 72% reversal rate of prediabetes to normoglycemia in the affected subpopulation