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Moreover, GLP-1R is found in the heart and blood vessels and is beneficial in heart rate, vascular endothelium, atherosclerosis, and hypertension [58, 59]

Understanding how Zepbound influences inflammatory pathways helps clinicians optimize patient selection and counseling, though it remains important to recognize that inflammation reduction is not an FDA-approved indication for this medication

During this activation phase, the adhesion molecule P-selectin is translocated to the cell surface and stored in endothelial cell Weibel Palade bodies and platelet granules (145)

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