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While remission of T2D is possible, particularly under intensive therapy, significant weight loss, and dietary adherence (Suleiman et al., 2022), it is not a stable state for most patients

System X c - /GSH/GPX4 axis : an important antioxidant system for the ferroptosis in drug-resistant solid tumor therapy

RBC Glutathione and Heavy Metals Correlation analysis found that baseline RBC glutathione (before DMSA) had significant positive correlations with urinary excretion of several metals (at baseline and after 9 th dose of DMSA), including baseline Sb (r = 0.26), and post-9th dose urinary excretion of Pb (r = 0.25), Al-9 (r = 0.29), and Cd (r = 0.30), suggesting that increased levels of these metals correlated with increased RBC glutathione

Thus, controlling ferroptosis, preventing excessive cell death, and developing drugs that selectively kill tumor cells without disrupting the immune microenvironment are key challenges requiring further research