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The benefits appear to be linked to increased serum Glutathione and benefits are seen within 24 hours of administration but also are persistent and cumulative with additional treatments

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The SUSTAIN-6 trial for semaglutide (3,297 patients, median 2.1 years), LEADER trial for liraglutide (9,340 patients, median 3.8 years), and REWIND trial for dulaglutide (9,901 patients, median 5.4 years) all included comprehensive adverse event monitoring