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A new consideration with respect to nano-bio interaction will be how different characteristics of the nanoparticles affect cellular uptake, escape from lysosomes, and the generation of oxidative stress within a cell 124

Importantly, the radiosensitising effects of metformin on both cell lines at 1.8 Gy were superior to the radiosensitising effects demonstrated by 5-FU, the current standard of care chemotherapeutic