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Fatigue that doesn't improve after four to six weeks at a stable dose, fatigue severe enough to interfere with daily function, or any fatigue accompanied by concerning symptoms is worth flagging with your prescriber

Recent rodent studies have also generated evidence suggesting that GIP action through GIPR lowers body weight and food intake via central neuronal signalling, given that these effects were not observed in CNS-GIPR knockout mice

Remember, this is a long-term lifestyle change, not a quick-fix diet trend, says Alicia Shelly, MD, a board-certified Internal Medicine and Diplomate of the American Board of Obesity Medicine at Wellstar Medical Center in Douglasville, GA

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