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Diosmetin-7-O--D-pyran glucoside (DG) and kaempferol can modulate M1/M2 macrophage polarization, suppress endotoxin-induced cytokine storms, enhance mouse survival rates, and concurrently limit viral activity and replication (296, 297)
Cessation stops the active stimulus, but the existing deposits of melanin in the tissue do not clear spontaneously in most cases
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