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Its function is unknown, but it may play a role in maintaining the structure or pH of this environment.[84] Murine models with variants in this gene had significantly decreased melanin production compared with normal controls.[85] In one international study of individuals with albinism, biallelic variants in OCA2 were found in 17% of participants.[86] Genetic variants in SLC45A2 ( MATP associated with OCA4), SLC24A5 (associated with OCA6), and TYRP1 (tyrosinase-related protein 1 associated with OCA3) are associated with less common types of oculocutaneous albinism

This means that internal health improvements often precede visible midsection changes

Nonetheless, these effects may be inadequate to reverse or arrest the progression of established, self-propagating intracerebral Alzheimers disease (AD) pathology, further supporting the prevention-dominant model

Overexpression of GSTs may contribute to increase detoxification of anticancer drugs 68