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Other approaches to anti-sickling gene therapy in erythroid-specific lentiviral vectors include utilizing a -globin gene with three specific point mutations that confer anti-sickling properties (ClinicalTrials.gov Identifier: NCT02247843) or the introduction of a -globin coding sequence in a -globin gene to increase HbF levels and decrease HbS (ClinicalTrials.gov Identifier: NCT02186418) ( (b) Hb F induction: The well-established efficacy of increasing HbF has motivated both pharmacological and genetic approaches to HbF induction

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doi:10.1016/s0022-510x(99)00169-0 [PubMed][CrossRef] 81