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Diabetes Obes Metab (2020) 22:93846

TRIUMPH-4 (Phase 3, 68 weeks) 12mg dose: 28.7% weight loss (~71 lbs / 32 kg average) 9mg dose: 26.4% weight loss (~64 lbs / 29 kg average) Patients also saw 76% reduction in knee osteoarthritis pain Blood pressure reduced by 14 mmHg on average Source: ClinicalTrials.gov (TRIUMPH-4, NCT05931367) The TRIUMPH Phase 3 program includes 4 trials studying retatrutide for obesity, type 2 diabetes, and cardiovascular outcomes

Physicians should inquire about these problems and monitor for them during therapy

The common thread, she said, tends to be a significant life change that alters their relationship to food and activity: a new job that keeps them moving, kids leaving the house, a reduction in chronic stress