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Some clinical experts and recent Phase 3 reporting have also noted that weight loss in some participants has been substantial enough to raise questions about how much weight loss may be too much, particularly when these medications are used outside tightly controlled medical settings and without provider supervision

Aggressive and dedifferentiated MTCs, paradoxically, may lose the ability to transcribe the CT/CGRP gene and thus a falling CT value may actually be an indicator of a poor prognosis (55)

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