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Serious heart valve problems or disease have been reported in patients taking a combination of phentermine and fenfluramine or dexfenfluramine for weight loss

Ma L, Peng S, Wei J, Zhao M, Ahmad KA, Chen J et al (2021) Spinal microglial -endorphin signaling mediates IL-10 and exenatide-induced inhibition of synaptic plasticity in neuropathic pain

The brief research report is published in Annals of Internal Medicine

Postal satiety, the signal that we're fooled, that's changing, and all of this together, these changes explain why just eat less and move more, becomes metabolically inefficient for many women midlife