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The modest clinical responses despite strong pre-clinical data support the contention that patients should be selected based on a tumor phenotype rather than histologic classification

Dhananjayan K, Gunawardena D, Hearn N, Sonntag T, Moran C, Gyengesi E, Srikanth V, Mnch G (2017) Activation of macrophages and microglia by interferon-gamma and lipopolysaccharide increases methylglyoxal production: a new mechanism in the development of vascular complications and cognitive decline in type 2 diabetes mellitus

While standard serum blood tests often fail to capture functional, tissue-level deficiencies, empirical treatment trials have shown profound benefits

For your body to make sufficient amounts, you also need adequate amounts of vitamin C, iron and vitamins B3 and B6