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specifically, larger and/or more invasive prolactinomas were found to be more likely to exhibit DA resistance, and MRI findings of substantial tumor mass or cavernous sinus invasion were also associated with resistance to DAs [3,7,14]

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The RT-qPCR results also indicated that the inflammatory factors IL-6 and TNF- increased significantly on day 1, but there were no significant differences compared to the NC group on days 2 and 3 (Fig