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Despite these promising developments, the clinical translation of nanoparticle-based strategies faces challenges including concerns regarding their stability in vivo and the need for further research to validate their safety and efficacy

Laboratory studies demonstrate that FOXO4-DRI effectiveness depends on senescent cell burden, tissue type, and the specific mechanisms maintaining senescent cell viability in different experimental conditions

Fujitsuka N, Asakawa A, Uezono Y, Minami K, Yamaguchi T, Niijima A, Yada T, Maejima Y, Sedbazar U, Sakai T, Hattori T, Kase Y, Inui A

The addition of 75 g/kg methyl-cobalamin injected twice weekly for one month further normalised GSH:GSSG