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It must also be considered whether these medications are delivered consistently over the entire duration of a trial, or whether they are given to achieve a certain weight loss, and then a maintenance intervention is used to aim to keep this weight off

These medications work through multiple complementary mechanisms: they enhance glucose-dependent insulin secretion, suppress inappropriate glucagon release, slow gastric emptying, and reduce appetitecollectively improving glycaemic control whilst minimising the risk of hypoglycaemia

In hepatocellular carcinoma (HCC), GLS2 inhibited proliferation in vitro and lung metastasis in a xenograft mouse model by inhibiting the small GTPase Rac1 13

SIRT3, a mitochondrial sirtuin deacetylase, regulates mitochondrial function and thermogenesis in brown adipocytes