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Patients should be counselled that sustainable weight management requires comprehensive lifestyle changes, and that injectable supplements are not a substitute for evidence-based interventions

Figure 1 Regulatory mechanism (Figure 1): The essence of ferroptosis lies in the depletion of glutathione (GSH) and the decline in the activity of glutathione peroxidase (GPX4), which leads to a reduction in the amount of glutathione reductase catalyzed by GPX4 and excessive accumulation of lipid peroxides ( 2+ oxidizes the accumulated lipid peroxides to generate ROS, resulting in an excessive accumulation of ROS and thus facilitating the occurrence of ferroptosis ( 2 Mechanisms of ferroptosis in ocular tissues 2.1 Dynamic balance of GSH and GPX4 In tissues rich in polyunsaturated fatty acids (PUFAs), such as the retina ( 2.2 Regulatory function of System Xc- System Xc- is a sodium-independent cystine-glutamate antiporter on the cell surface

Slowly releases growth factors over weeks and months