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These studies highlighted several anti-cancer effects exerted by metformin on TC cells including: i) induction of cell death, ii) reduction of cell growth, iii) inhibition of the metastatic potential iv) modulation of chemokines in the tumor microenvironment, v) de-differentiating effects (increase in iodine up-take) (Klubo-Gwiezdzinska et al., 2013

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Brain 130:20452054 Rath S, Sharma R, Gupta R, Ast T, Chan C, Durham TJ et al (2021) MitoCarta3.0: an updated mitochondrial proteome now with sub-organelle localization and pathway annotations