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Severe SARS-CoV-2 infection with high cytokine levels causes T-cell exhaustion characterized by high levels of programmed cell death protein 1 and low numbers of CD4 + and CD8 + cells (Diao et al., 2020

The time-dependent monitoring by confocal laser scanning microscopy (CLSM) indicated that with longer incubation time, an increasing fluorescence intensity of NP4-Cy5.5 was detected in the cancer cells (Fig

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