nausea and headache from semaglutide Does Cause Headaches? Treatment with GLP-1 receptor agonists

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The three steps in the synthesis of BH4 all use different enzymes that can be affected by genetic variants: The first step uses GTP cyclohydrolase I (GCH1 gene , in the genotype report) The second step uses 6-pyruvoyltetrahydrobiopterin synthase (PTS gene) The final step is catalyzed by sepiapterin reductase ( SPR gene ).[ref] Variants in the GCH1 and SPR genes impact the availability of BH4