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Beyond potency loss, expired injectables stored at room temperature can develop bacterial or fungal contamination, especially if the pen's rubber septum (the puncture point) has been breached multiple times

Older testimonials may also reflect experiences with compounded GLP-1s no longer offered to new patients

Current guidelines do not recommend combination therapy with GLP-1 RAs and DPP-4 inhibitors, and the ADA/EASD consensus report specifically recommends discontinuation of DPP-4 inhibitors when initiating GLP-1 RA therapy

Glutathione contributes to this by helping the synthesis of protective compounds like glutathione peroxidase