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The recommended dietary allowance (RDA) for most adults is 2.4 mcg per day, though some may need more based on specific health considerations

This B12-intrinsic factor complex travels to the terminal ileum, where it binds to specific receptors and is absorbed into the bloodstream

Acute toxicity studies in animals, if extrapolated to humans, implicate a single dose of 10-15 grams necessary to produce significant liver toxicity, although several human case reports have shown toxicity at doses less than 4 grams per day (likely due to having one or more risk factors for sensitivity to toxicity) (Amar 2007)

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