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Intercrossing Cre + and Cre Dpp4 loxP heterozygotes resulted in 4 genotypes: WT mice with no Cre recombinase, mice homozygous for LoxP sites within the Dpp4 gene ( Dpp4 fl/fl ), WT mice expressing Cre recombinase ( Tie2-Cre and Vil1-Cre ), and Dpp4 fl/fl mice expressing Cre recombinase ( Dpp4 EC/ and Dpp4 Gut/ )

Some examples of the natural substrates of DPP-4 are enumerated below in Table 1, (Zhong et al., 2013): Table 1: Examples of natural substrates of DPP4 and the effect of DPP4 action on them

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These hormones work to stimulate insulin release, reducing the release of glucarukons and hormones that increase blood sugar