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L-Carnitine supplementation an lead to improvements in several complications seen in uremic patients, including cardiac complications, impaired exercise and functional capacities, muscle symptoms, increased symptomatic intradialytic hypotension, and erythropoietin-resistant anemia through normalizing the reduced carnitine palmitoyl transferase activity in red cells [43]

A positive control analysis was conducted to validate the genetic instruments for GLP-1R by verifying the association of genetic instruments from eQTLs with type 2 diabetes, given that GLP-1R agonists are FDA-approved for blood glucose and weight control

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doi: 10.1016/j.semcdb.2017.07.013 65 PandeyV