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Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA

If you develop severe allergic reactions such as difficulty breathing, facial swelling, or widespread rash after a B12 injection, call 999 or go to A&E immediately, as these may indicate anaphylaxis, though this is extremely rare

The damage caused by SAP to the vascular endothelium is manifested as the release of inflammatory mediators and leukocyte adhesion, increased vascular permeability, changes in blood flow shear stress, microthrombosis, and microcirculatory disorders