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In thalassemia, these symptoms come from anemia caused by bad blood cell production

Key finding: Genetic NNMT knockdown increased energy expenditure, reduced adipose tissue by 30% , and elevated NAD+ and SAM levels validating NNMT as a high-value target

With further research, it is expected to transform from a research tool into a clinical drug, filling the niche in targeted metabolic therapy, especially in the combined intervention of obesity and type 2 diabetes, where it holds unique application potential