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For instance, tryptophan metabolites acting on the aryl hydrocarbon receptor (AhR) are decreased in MS, and stimulating AhR in astrocytes and microglia has been shown to reduce CNS inflammation [192, 193]

Brunger, a Howard Hughes Medical Institute investigator, shares senior authorship of the study with Burton Dickey, MD, a professor of pulmonary medicine at the MD Anderson Cancer Center in Houston, and Manfred Frick, PhD, a professor of medicine at Ulm University in Germany

Differential protein abundance by empirical Bayes was performed to identify proteins reaching statistical significance