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4.1
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Description

Molecular weight approximately 1,419 Da, small enough to cross most biological barriers including the blood-brain barrier in animal models

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As such, depending upon the otic agent used, the thickness or viscosity desired, or the mode of delivery chosen, alternative aspects of the embodiments disclosed herein are combined with the immediate release, delayed release and/or extended release embodiments accordingly

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Therefore, this approach most likely underestimated the actual vessel density during the resting phase

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