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Clin Exp Pharmacol Physiol 24:907915 Miners JO, Knights KM, Houston JB et al (2006) In vitro-in vivo correlation for drugs and other compounds eliminated by glucuronidation in humans: pitfalls and promises

In a 15 year study, elderly humans treated with intermittent courses of epithalamin (the natural polypeptide source of epithalon) had longer survival rates, better cardiovascular health, fewer pulmonary illnesses, improved carbohydrate and lipid metabolism, and better physical endurance compared to controls [4]

Age-related decline GH secretion declines with age, but pharmacologically increasing GH in otherwise healthy older adults can produce edema, arthralgia, glucose intolerance, and other adverse effects

Conflicts of interest Frhbeck G received honoraria from Lilly, Novo Nordisk, Regeneron, AstraZeneca and Boehringer Ingelheim as a member of advisory boards, and honoraria for lectures as a member of the OPEN Spain Initiative