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Use: In combination with a reduced calorie diet and increased physical activity, for the treatment of noncirrhotic MASH with moderate to advanced liver fibrosis (consistent with stages F2 to F3 fibrosis) Usual Pediatric Dose for Weight Loss 12 YEARS AND OLDER: Wegovy Injection: Initial dose (weeks 1 through 4): 0.25 mg subcutaneously once a week Dose escalation: Weeks 5 through 8: 0.5 mg subcutaneously once a week Weeks 9 through 12: 1 mg subcutaneously once a week Weeks 13 through 16: 1.7 mg subcutaneously once a week Alternatively: 1.7 mg subcutaneously once a week Comments: The recommended maintenance dose is 2.4 mg

Bernaerts, S., Boets, B., Bosmans, G., Steyaert, J

Post-Reconstitution Care and Light Exposure Once you transition the powder to a liquid solution, shield the vial from ambient light exposure and maintain cold storage at 2C to 8C

Cytochrome c binds to the apoptotic peptidase activating factor 1 (Apaf-1), forming an apoptosome with consequent downstream activation of caspase-9 and caspase-3