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For that reason, the pill must be taken: On a completely empty stomach First thing in the morning At least 30 minutes before eating, drinking anything but water, or taking other medications This schedule can create a practical conflict for patients already taking medications that require an empty stomachsuch as levothyroxine (for thyroid conditions) or omeprazole (for acid reflux)

Melzer C, von der Ohe J, Hass R

Clinical trials demonstrate remarkable efficacy in treating withdrawal symptoms, with 97% of opiate-dependent and 87% of alcohol-dependent patients experiencing symptom relief