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Some researchers have also voiced concern that a 25 to 30 percent reduction in body weight could compromise some patients health, perhaps by leading to nutritional deficiencies or loss of muscle mass

In a randomized, single-blind, 24-week study, participants assigned to dual therapy of 2 mg weekly of the GLP-1 receptor agonist exenatide (Bydureon, AstraZeneca) and 10 mg daily of the SGLT2 inhibitor dapagliflozin (Farxiga, AstraZeneca) lost more weight than those taking either agent alone or those receiving dapagliflozin and metformin extended-release (Xigduo XL, AstraZeneca) or phentermine/topiramate extended-release (Qsymia, Vivus)

The average weight loss on retatrutide depends on the dose and trial

When weight falls quickly, those compartments lose volume faster than the overlying skin can fully retract