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The LEAD-1 study provided clinical input and compared glimepiride with two doses of liraglutide (1.2 mg and 1.8 mg) and rosiglitazone (4 mg) in patients with type 2 diabetes mellitus (T2DM) (16)

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In summary IGF-1 LR3 and IGF DES 1,3 have benefits for muscle growth, muscle mass and physical performance but should be used with caution